广西医学

目的探讨宫颈癌生存者经济毒性现状及其影响因素。方法采用便利抽样方法选取200例宫颈癌生存者作为研究对象，采用一般资料调查表、患者报告结局的经济毒性综合评分（COST⁃PROM）量表、社会支持评定量表（SSRS）、简易应对方式问卷（SCSQ）对其进行调查。比较不同临床特征患者的COST⁃PROM量表总分，并分析患者SSRS总分及SCSQ分量表得分与COST⁃PROM量表总分的相关性。采用多元线性逐步回归模型分析宫颈生存者经济毒性的影响因素。结果宫颈癌生存者COST⁃PROM量表总分为20.00（14.00，24.00）分，经济毒性发生率为76.5%。不同年龄、文化程度、子女经济情况、家庭人均月收入、医保类型、职业类型、是否重返工作、疾病分期、住院次数、治疗方式、化疗次数、放疗次数、社会支持程度、应对方式的宫颈癌生存者之间的COST⁃PROM量表总分比较，差异有统计学意义（P<0.05）。COST⁃PROM量表总分与SSRS总分、SCSQ中的积极应对分量表得分呈正相关，与SCSQ中的消极应对分量表得分呈负相关（P<0.05）。多元线性逐步回归分析结果显示，年龄、子女经济情况、家庭人均月收入、医保类型、疾病分期、治疗方式、社会支持程度是宫颈癌生存者经济毒性的主要影响因素（P<0.05）。结论宫颈癌生存者的经济毒性较严重，年龄、子女经济情况、家庭人均月收入、医保类型、疾病分期、治疗方式、社会支持程度是宫颈癌生存者经济毒性的影响因素。

Objective To explore the current status of economic toxicity of cervical cancer survivors and its influencing factors. Methods A total of 200 cervical cancer survivors were selected as the research subjects by employing the convenience sampling method. Investigation was performed on the research subjects by using general data inventory, Comprehensive Scores for Financial Toxicity Based on The Patient⁃Reported Outcome Measures (COST⁃PROM) scale, Social Support Rating Scale (SSRS), and Simplified Coping Style Questionnaire (SCSQ). The total score of COST⁃PROM scale was compared between patients with different clinical characteristics, and the correlation of patients' SSRS total score and patients' subscale score of SCSQ with COST⁃PROM scale total score was analyzed. The multiple linear stepwise regression model was used to analyze the influencing factors for economic toxicity of cervical cancer survivors. Results The total score of COST⁃PROM scale in cervical cancer survivors was 20.00 (14.00, 24.00), with the incidence rate of economic toxicity in 76.5%. There was a statistically significant difference in COST⁃PROM scale total score between cervical cancer survivors with different age, educational level, children's financial situation, per capita monthly household income, medical insurance type, occupational type, back to work or not, disease classification, hospitalization frequency, therapeutic method, chemotherapy frequency, radiotherapy frequency, social support level, and coping style (P<0.05). COST⁃PROM scale total score positively correlated with SSRS total score, and subscale score of positive coping in SCSQ, whereas negatively correlated with negative coping subscale score in SCSQ (P<0.05). The results of multiple linear stepwise regression analysis revealed that age, children's financial situation, per capita monthly household income, medical insurance type, disease classification, therapeutic method, and social support level were the main influencing factors for economic toxicity of cervical cancer survivors (P<0.05). Conclusion Economic toxicity of cervical cancer survivors is relatively serious, age, children's financial situation, per capita monthly household income, medical insurance type, disease classification, therapeutic method, and social support level are the influencing factors for economic toxicity of cervical cancer survivors