Objective To investigate the correlation between liver fibrosis and symptomatic intracranial hemorrhage (sICH) occurrence after endovascular therapy in patients with acute ischemic stroke (AIS). Methods Eighty patients with AIS were selected as the research subjects, and they were assigned to sICH group or non⁃sICH group according to whether sICH after endovascular therapy occurred or not. The clinical data were compared between patients of the two groups. The risk factors for sICH occurrence after AIS patients' endovascular therapy were analyzed by employing the multivariate Logistic regression model. The receiver operating characteristic (ROC) curve was drawn to analyze the efficiency of fibrosis index based on the four factors (FIB⁃4) for predicting sICH. Results After 36 hours of endovascular therapy, 15 (18.75%) patients suffered from sICH. There were statistically significant differences in age, National Institutes of Health Stroke Scale (NIHSS) score at admission, FIB⁃4 at admission between the sICH group and the non⁃sICH group (P<0.05). The results of multivariate Logistic regression analysis revealed that high score of NIHSS at admission, high FIB⁃4 at admission, and advanced age were the risk factors for AIS patients suffering from sICH after endovascular therapy (P<0.05). The results of ROC curve indicated that area under the curve of FIB⁃4 for predicting sICH in AIS patients after endovascular therapy was 0.815. Conclusion FIB⁃4 at admission correlates with sICH occurrence in AIS patients after endovascular therapy, and it may be regarded as predictor for sICH.

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