Objective To analyze the current status of early psychosocial adjustment in patients with glioma after surgery and its influencing factors. Methods A total of 119 patients with glioma undergoing postoperative adjuvant chemoradiotherapy were selected as the research subjects. The general data inventory, self⁃report psychosocial adjustment to illness scale, Cognitive Appraisal of Health Scale (CAHS), Medical Coping Modes Questionnaire (MCMQ) were employed to perform investigation on them, and the influencing factors for early psychosocial adjustment of patients were analyzed by using the multivariate linear regression model. Results The score of self⁃report psychosocial adjustment to illness scale was 76.02±13.17 in patients with glioma during early postoperative period, which belonged to relatively poor level. There were statistically significant differences in the score of self⁃report psychosocial adjustment to illness scale between patients with glioma during early postoperative period who had different per capita monthly household incomes, different disease sites, different main caregivers, and suffered from a second surgery (P<0.05). Self⁃report psychosocial adjustment to illness scale score positively correlated with CAHS total score and the scores of challenge dimension, harmfulness/losing dimension, and threat dimension in CAHS, whereas negatively correlated with the score of helpfulness/irrelevance dimension in CAHS, as well as positively correlated with MCMQ total score and the scores of confronting dimension, avoidance dimension, and yielding dimension of MCMQ (P<0.05). Per capita monthly household income, main caregivers, second surgery, medical coping, and cognitive assessment were the influencing factors for early psychosocial adjustment in patients with glioma after surgery (P<0.05). Conclusion Early psychosocial adjustment of patients with glioma after surgery belongs to relatively poor level. Per capita monthly household income, main caregivers, second surgery, cognitive assessment, and medical copying are the influencing factors for early psychosocial adjustment in patients with glioma after surgery.