Objective To investigate the current status of cancer⁃related cognitive impairment (CRCI) in patients with nasopharyngeal carcinoma, and to analyze the influencing factors for CRCI. Methods A total of 200 patients with nasopharyngeal carcinoma were selected as the research subjects. The general data of patients were collected. The Montreal Cognitive Assessment (MoCA) scale, Chinese Version of Brief Fatigue Inventory (BFI⁃C), and Hospital Anxiety and Depression Scale (HADS) were employed to performed questionnaire investigation. Results A total of 125 (62.50%) cases, 149 (74.50%) cases, 114 (57.00%) cases suffered from CRCI, anxiety, depression among 200 patients with nasopharyngeal carcinoma, and the overall fatigue level was moderate. Cognitive function negatively correlated with fatigue, anxiety, and depression in patients with nasopharyngeal carcinoma (P<0.05). Educational level was the protective factor for CRCI in patients with nasopharyngeal carcinoma, and fatigue, anxiety, and depression were the risk factors for CRCI in patients with nasopharyngeal carcinoma (P<0.05). Conclusion Patients with nasopharyngeal carcinoma commonly suffer from CRCI. Medical and nursing personnel should focus on patients with nasopharyngeal carcinoma who have low educational level, and suffer from fatigue and negative emotions; moreover, they should formulate targeted, systematic and effective cognitive rehabilitation intervention strategies, so as to promote patients to adapt and participate in society.  

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