Objective To explore the clinical effect of trans⁃meridian multi⁃dimensional nodes disentangling of Zhuang Medicine for the treatment of lumbar disc herniation (LDH). Methods A total of 70 LDH patients were randomly divided into control group or treatment group, with 35 cases in each group. The control group was treated with Traditional Chinese Medicine massage plus ordinary acupuncture plus cupping, whereas the treatment group was treated with Zhuang Medicine trans⁃meridian massage plus Zhuang Medicine fire needle acupuncture plus cupping. Both groups were treated once every other day, for 5 times in total. The pre⁃ and post⁃treatment Japanese Orthopaedics Association (JOA) score, Visual Analogue Scale (VAS) score for pain, serum level of tumor necrosis factor α (TNF⁃α), as well as clinical efficacy were compared between the two groups. Results The total effective rate of treatment in the treatment group was 94.29%, which was higher than that in the control group (77.14%, P<0.05). After treatment, JOA score of both groups was elevated, whereas VAS score for pain, and serum TNF⁃α level were decreased as compared with before treatment; moreover, compared with the control group, the treatment group yielded a higher JOA score and lower VAS score for pain and serum TNF⁃α level (P<0.05). Conclusion Compared with routine Traditional Chinese Medicine therapy, trans⁃meridian multi⁃dimensional nodes disentangling of Zhuang Medicine exerts superior effect to the treatment of LDH patients, and can significantly ameliorate patients' clinical symptoms and pain degree, decrease serum TNF⁃α level, which is worthy of clinical application and promotion.