Objective To explore the influence on bupivacaine liposomes applying to pericapsular nerve group block (PNGB) on analgesic effect in senile patients with intertrochanteric fracture of femur after surgery. Methods A total of 80 senile patients with intertrochanteric fracture of femur who were proposed to receive surgical treatment were selected as the research subjects, and they were randomly assigned to observation group or control group, with 40 cases in each group. The observation group received bupivacaine liposomes for PNGB, whereas the control group received bupivacaine hydrochloride for PNGB. Visual Analogue Scale (VAS) score for resting pain and VAS score for exercise pain at different time points before and after surgery, fentanyl demand at different time points after surgery, and the incidence rate of postoperative nausea and vomiting were compared between patients of the two groups. Results The observation group exhibited lower VAS scores for resting pain and exercise pain as compared with the control group 6, 12, 48, and 72 hours after surgery (P<0.05). The observation group yielded lower fentanyl demand as compared with the control group 12, 24, and 48 hours after surgery (P<0.05). The incidence rate of nausea and vomiting in the observation group after surgery was lower than that in the control group (P<0.05). Conclusion For senile patients with intertrochanteric fracture of femur, employing bupivacaine liposomes for PNGB can provide more effective postoperative analgesic effect, reduce patients' demands for analgesic drug after surgery, and decrease the incidence rate of nausea and vomiting after surgery.

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