广西医学

目的分析2014—2022年广西壮族自治区（简称广西）人间布鲁氏菌病（简称布病）的流行特征和时空分布特征，为制定防控措施提供科学依据。方法布病报告病例数据来源于中国疾病预防控制信息系统。应用JoinPoint 5.2.0.0软件对2014—2022年布病发病率进行趋势分析；应用ArcGIS 10.8软件对布病发病率空间分布进行可视化和空间自相关分析；应用SaTScan 10.1.3软件对布病发病率进行时空扫描分析。结果 2014—2022年广西报告人间布病病例1 523例，年平均发病率为0.34/10万，整体呈现上升趋势［平均年度变化百分比（AAPC）=41.37%，P<0.05］；发病高峰期在3—8月。男性、50~59岁、农牧民人群发病率最高。2015—2022年广西各县（区）人间布病发病率呈聚集性分布（全局莫兰指数值均>0，P<0.05）。局部空间自相关分析结果显示，“高-高”聚集的县（区）主要集中在桂林市、贺州市、柳州市和来宾市。时空扫描共探测到4个时空聚集区，聚集的县（区）主要集中在贺州市、桂林市、柳州市、玉林市及贵港市，聚集时间分别为2016年、2017年、2021年和2022年。结论 2014—2022年广西人间布病流行仍呈上升趋势，发病人群以农牧民及中老年人为主，发病存在时空聚集性，时空聚集区主要集中在贺州市、桂林市、柳州市、玉林市及贵港市。

Objective To analyze the epidemiological and spatiotemporal distribution characteristics of brucellosis in humans in Guangxi Zhuang Autonomous Region (hereinafter referred to as Guangxi) from 2014 to 2022, so as to provide a scientific basis for the formulation of prevention and control measures. Methods The reported brucellosis in humans case data were obtained from the China Disease Prevention and Control Information System. The JoinPoint 5.2.0.0 software was adopted to perform trend analysis of the morbidity of brucellosis in humans from 2014 to 2022. The ArcGIS 10.8 software was employed for visualization and spatial auto⁃correlation analysis of spatial distribution of brucellosis in humans morbidity. The SaTScan 10.1.3 software was used for spatiotemporal scanning analysis of brucellosis in humans morbidity. Results From 2014 to 2022, a total of 1523 brucellosis in humans cases were reported in Guangxi, with an average annual morbidity of 0.34 per 100 000, showing an overall upward trend (average annual percentage change ［AAPC］=41.37%, P<0.05). The peak of disease onset occurred from March to August. The highest morbidity was observed among males, individuals aged 50 to 59, and farmers/herders. From 2015 to 2022, the morbidity of brucellosis in human in Guangxi's counties (districts) exhibited a clustered distribution (global Moran's values all>0, P<0.05). The results of local spatial auto⁃correlation analysis revealed that “high⁃high” clustering counties (districts) were mainly concentrated in Guilin, Hezhou, Liuzhou, and Laibin. Spatiotemporal scanning detected a total of four spatiotemporal clusters, primarily located in Hezhou, Guilin, Liuzhou, Yulin, and Guigang, with clustering periods in 2016, 2017, 2021, and 2022, respectively. Conclusion From 2014 to 2022, the prevalence of brucellosis in humans in Guangxi continues to rise, with farmers/herders and middle⁃aged/elderly individuals being the most affected populations. The disease exhibits spatiotemporal clustering, with spatiotemporal clusters mainly concentrated in Hezhou, Guilin, Liuzhou, Yulin, and Guigang.