Objective To explore the influencing factors for patients with type 2 diabetes mellitus (T2DM) suffering from cardiac autonomic neuropathy (CAN). Methods A total of 351 T2DM patients were selected as the research subjects, according to the results of cardiovascular autonomic reflex test, they were assigned to CAN group (n=135) or non⁃CAN group (n=216). General clinical data, laboratory indices, body composition analysis indices were compared between the two groups. The multivariate Logistic regression model was employed to analyze the influencing factors for T2DM patients suffering from CAN. Results A total of 135 patients suffered from CAN among 351 T2DM patients, resulting in the incidence rate of 38.46%. Compared with the non⁃CAN group, the CAN group exhibited higher age, systolic blood pressure, and a longer disease course of diabetes mellitus, a lower triglyceride level, a higher HbA1c level, lower skeletal muscle mass (SMM), as well as a higher proportion of hypertension history (P<0.05). The results of multivariate Logistic regression analysis revealed that T2DM patients with advanced age, high systolic blood pressure, elevated HbA1c level, decreased SMM had a higher risk of suffering from CAN (P<0.05). Conclusion The incidence rate of T2DM patients suffering from CAN is high, patients with more advanced age, higher systolic blood pressure, higher HbA1c level, and lower SMM more easily suffer from CAN.

无