Objective To understand the actual situation of medical quality supervision and management of Guangxi public hospitals, so as to provide references for further improving medical quality supervision and management system of public hospitals. Methods The current status of medical quality supervision and management in 323 class Ⅱ and Ⅲ public hospitals (99 class Ⅲ hospitals and 224 class Ⅱ hospitals) in 14 cities of establishing districts in Guangxi was investigated by questionnaire. Results There were 320 (99.07%) public hospitals with two or more levels of quality management organization. Hospitals in 51.08% (165/323) had established a monthly quality and safety magazine, more than 95% hospitals had organized medical personnel to conduct relevant assessments, and 90.71% (293/323) hospitals linked the completion of medical quality⁃associated summaries, indices, training, etc., with the performance evaluation of their departments. At the hospital level, 21.05% (68/323) hospitals held one or more meetings of medical quality management per month; in addition, at the department level, only 6.50% (21/323) hospitals had realized a weekly meeting of medical quality management organized by department heads. Hospitals in 97.21% (314/323) had carried out quality and safety training, but 2.79% (9/323) hospitals had never carried out quality and safety training. The commonly used quality management tools in class Ⅲ hospitals were clinical pathway management (accounting for 93.94%) and PDCA cycle (accounting for 91.92%), and in class Ⅱ hospitals was clinical pathway management (accounting for 80.36%). Only 25.38% (82/323) hospitals had established platform for medical quality information⁃based supervision. Conclusion The medical quality management of Guangxi public hospitals is faced with such problems as insufficient coordination of management and organization, imperfect supervision mechanism, and insufficient support and guarantee capacity, as well as a lack of motivation mechanism and incentive mechanism. It is recommended to promote the organization and coordination of medical quality management, improve the supervision and management mechanism of medical quality, and strengthen the construction of medical quality support and guarantee.