Objective To evaluate the management effect of localized clinical pathway on single⁃disease control indices in the National Performance Assessment of Tertiary Public Hospitals (referred to as National Assessment), so as to provide references for improving single⁃disease management effect. Methods Patients with cerebral infarction receiving medical treatment in a class Ⅲ level A hospital were selected as the research subjects. Patients in Inpatient Ward A, where localized clinical pathway was implemented, were assigned to experimental group, while those in Inpatient Ward B without localized clinical pathway were served as control group. Propensity score matching (PSM) was used to match the data of patients in both groups, with 162 patients in each group finally included. A difference⁃in⁃differences model was applied to assess the management effects of localized clinical pathway on National Assessment single⁃disease control indices, including hospitalization costs and length of hospital stay, etc. Results After implementing localized clinical pathway, the total hospitalization costs for patients with cerebral infarction receiving medical treatment decreased by 7645.25 yuan, with medical service fees reduced by 4665.26 yuan, medication costs by 2966.11 yuan, and material expenses by 196.26 yuan. Additionally, the length of hospital stay shortened by 4.51 days (P<0.05). Conclusion The adoption of localized clinical pathway for single⁃disease quality control in the National Assessment can reduce medical service fees, medication costs, and material expenses while shortening length of hospital stays. Public hospitals should refine clinical pathway management systems and accelerate the localization of clinical pathway.

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