Objective To explore the medication rules of Traditional Chinese Medicine for the treatment of posthepatitic cirrhosis based on data mining technique. Methods Literature on Traditional Chinese Medicine for the treatment of posthepatitic cirrhosis was retrieved from the China National Knowledge Infrastructure database, and relevant Traditional Chinese Medicine prescriptions were screened and enrolled for a database construction. Descriptive statistical analysis was performed using Microsoft Excel 2021 to evaluate the frequency of use, properties, flavors, meridians, and efficacy of Traditional Chinese Medicines. Association rule analysis was conducted using IBM SPSS Modeler 18.0 software, and systematic cluster analysis was performed using IBM SPSS Statistics 25.0 software. Results A total of 191 literature was included, involving 222 Traditional Chinese Medicine prescriptions and 236 flavors of Traditional Chinese Medicines. Among them, 29 high⁃frequency Traditional Chinese Medicines (used ≥30 times) were identified, with the top 5 being Atractylodes macrocephala, Poria cocos, Salvia miltiorrhiza, Astragalus membranaceus, and Trionycis carapax. The properties of the 236 Traditional Chinese Medicines were primarily cold, followed by warm and moderate, the flavors were mainly bitter, sweet, and acrid; the meridians primarily belonged to spleen meridian, liver meridian, stomach meridian, lung meridian, and heart meridian, and the main efficacy was tonifying deficiency, activating blood circulation and resolving stasis, and promoting diuresis and draining dampness. Association rule analysis yielded 1 pair of two⁃drug combinations, 4 three⁃drug combinations, 11 four⁃drug combinations, and 3 five⁃drug combinations, with core drugs including Atractylodes macrocephala, Poria cocos, Salvia miltiorrhiza, Astragalus membranaceus, and Trionycis carapax. Through systematic cluster analysis and combined with Traditional Chinese Medicine efficacy knowledge, the 29 high⁃frequency Traditional Chinese Medicines were clustered into 8 categories. Conclusion Traditional Chinese Medicine for the treatment of posthepatitic cirrhosis primarily focuses on strengthening spleen and soothing liver, activating blood circulation and resolving stasis, and clearing heat, detoxifying, and draining dampness. Commonly used drugs include Poria cocos, Atractylodes macrocephala, Salvia miltiorrhiza, Trionycis carapax, and Astragalus membranaceus, adhering to the principle of combining multiple drugs and addressing both symptoms and root causes.  

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