Objective To explore the application effect of bone cement tailoring technique in percutaneous kyphoplasty (PKP) for treating Kümmell's disease. Methods The clinical data of 40 patients with Kümmell's disease undergoing PKP therapy were retrospectively analyzed. Patients were divided into non⁃tailoring group (n=18) or tailoring group (n=22) according to whether bone cement tailoring technique was applied or not during surgery. Perioperative indices (operation duration, intraoperative fluoroscopy frequency, intraoperative bleeding loss, injection volume of bone cement, length of hospital stay), and pre⁃ and postoperative Visual Analog Scale (VAS) score for low back pain, lumbar vertebral function [Oswestry disability index (ODI) score, Cobb angle, relative height of anterior edge of affected vertebra], quality of life (36⁃Item Short⁃Form Health Survey [SF⁃36]), and the occurrence of 1⁃year postoperative complications were compared between the two groups. Results (1) No statistically significant difference was observed in operation duration, intraoperative fluoroscopy frequency, intraoperative bleeding loss, injection volume of bone cement, and length of hospital stay between the two groups (P>0.05). (2) After surgery, VAS score for low back pain, ODI score of both groups, and Cobb angle in the tailoring group exhibited a trend of decline over time, whereas SF⁃36 score and relative height of anterior edge of affected vertebra of both groups revealed a trend of increase over time (P<0.05). One day and one year after surgery, Cobb angle of the non⁃tailoring group was smaller as compared with before surgery (P<0.05). One day and one year after surgery, compared with the non⁃tailoring group, the tailoring group exhibited lower VAS score for low back pain, ODI score, and smaller Cobb angle, whereas higher SF⁃36 score and relative height of anterior edge of affected vertebra (P<0.05). (3) There was no statistically significant difference in the incidence rate of complications between the two groups (P>0.05). Conclusion The application of bone cement tailoring technique in PKP for the treatment of Kümmell's disease is superior to that without bone cement tailoring technique. The technique can effectively relieve the postoperative low back pain of patients with Kümmell's disease, promote the recovery of lumbar vertebral function, improve the quality of life, exerting a favorable safety.