Objective To analyze the association between depressive symptoms and WeChat use⁃pattern in college students, and the moderating effect of social support. Methods The stratified cluster sampling method was used to perform a questionnaire survey among 668 undergraduates from a medical college. The survey included general information, depression symptoms with respect to total score of Center for Epidemiological Studies Depression Scale (CES⁃D), WeChat use⁃pattern (WeChat use⁃pattern scale), social support (Perceived Social Support Scale [PSSS]score), personality trait, etc. The relation of WeChat use⁃pattern and social support with depressive symptoms, and the moderating effect of social support between WeChat use⁃pattern and depressive symptoms were analyzed by employing the binary Logistic regression method. Results CES⁃D total score among 668 college students was 12 (6, 12), with the detection rate of depressive symptoms of 37.13%, and PSSS total score was 63 (55, 69), as well as scores of family support dimension, friends support dimension, and others support dimension were 23 (19, 26), 19 (16, 20), and 21.36±4.35, respectively; furthermore, scores of direct communication dimension, information issue dimension, and information receiving dimension of WeChat use⁃pattern scale were 23 (19, 28), 12 (9, 16), and 20 (18, 23), respectively. The results of binary Logistic regression analysis revealed that after adjusting for relevant confounding factors, depressive symptoms positively correlated with information issue of WeChat use⁃pattern (P<0.05). The total level of social support exerted the moderating effect between WeChat use⁃pattern and depressive symptoms, therein family support level exerted the positive moderating effect between different WeChat use⁃patterns and depressive symptoms (P<0.05). Conclusion WeChat use⁃patterns have different effects on depressive symptoms of college students, and frequent information issue may be detrimental to mental health. Social support, especially family support, can play a positive role in moderating the relationship.