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论著·临床研究 | 更新时间:2025-11-05
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成人破伤风患者发生胃肠功能紊乱的现状及影响因素分析
Current status and influencing factors for the occurrence of gastrointestinal dysfunction in adult tetanus patients: an analytic study

广西医学 页码:1431-1438

作者机构:王洋芳,在读硕士研究生,研究方向为传染病护理及管理。

基金信息:南宁市科学研究与技术开发计划(20213025⁃1、20193008⁃4)

DOI:10.11675/j.issn.0253⁃4304.2025.10.08

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目的 分析成人破伤风患者胃肠功能紊乱的现状及影响因素。方法 回顾性分析192例成人破伤风患者的临床资料,根据患者住院期间是否并发胃肠功能紊乱分为胃肠功能紊乱组和胃肠功能正常组。比较两组患者的一般资料、临床特征资料、实验室检查资料,采用二元Logistic回归模型分析成人破伤风患者发生胃肠功能紊乱的影响因素。结果 192例成人破伤风患者中,98例发生胃肠功能紊乱,发生率为51.04%。二元 Logistic 回归分析结果显示,使用肌松剂、肠内营养治疗、镇静剂使用时间长、使用抑酸剂是成人破伤风患者发生胃肠功能紊乱的独立危险因素(P<0.05)。结论 成人破伤风患者的胃肠功能紊乱发生率较高,临床工作中医护人员应密切观察该类患者肌松剂、镇静剂、肠内营养及抑酸剂的使用情况,及时评估病情进展,改善患者预后。

Objective To analyze the current status and influencing factors for gastrointestinal dysfunction in adult tetanus patients. Methods The clinical data of 192 adult tetanus patients were retrospectively analyzed, and patients were assigned to gastrointestinal dysfunction group or normal gastrointestinal function group according to the presence of concomitant gastrointestinal dysfunction during hospitalization. General data, clinical characteristic data, laboratory test data were compared between patients of the two groups. The binary Logistic regression model was adopted to analyze the influencing factors for the occurrence of gastrointestinal dysfunction in adult tetanus patients. Results Among 192 adult tetanus patients, 98 cases had gastrointestinal dysfunction, with the incidence rate of 51.04%. The results of binary Logistic regression analysis revealed that the use of muscle relaxants, enteral nutrition therapy, sedative use duration and use of acid suppressants were independent risk factors for the occurrence of gastrointestinal dysfunction in adult tetanus patients (P<0.05). Conclusion Adult tetanus patients have a high incidence rate of suffering from gastrointestinal dysfunction. In clinical work, medical personnel should closely observe the uses of muscle relaxants, sedatives, enteral nutrition and acid suppressants to evaluate disease progression in time, improve patients' prognosis.

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