Objective To analyze the potential categories and influencing factors of family resilience in elderly patients undergoing maintenance hemodialysis (MHD), providing reference for formulating clinical predictive nursing and intervention strategies. Methods A total of 296 elderly MHD patients were selected as the research subjects, and they were investigated with the general information questionnaire, Family Resilience Questionnaire, Chinese version of Connor⁃Davidson Resilience Scale, Family Apgar index and Chinese version of Medical Outcomes Study Social Support Survey. Latent profile analysis was performed on family resilience of elderly MHD patients, and multivariate Logistic regression model was adopted to analyze and explore the influencing factors for different categories of family resilience. Results The family resilience of elderly MHD patients could be divided into three potential categories as follows: low level of family resilience group (n=59, 19.9%), medium level of family resilience group (n=152, 51.4%) or high level of family resilience and low openness group (n=85, 28.7%). The results of multivariate Logistic regression analysis revealed that the influencing factors for family resilience of elderly MHD patients included family monthly income per capita, marital status, educational level, dialysis duration, family care, psychological resilience and medical social support level (P<0.05). Conclusion The level of family resilience in elderly MHD patients is obviously heterogeneity, and is affected by factors such as family monthly income per capita, marital status, educational level, dialysis duration, family care, psychological resilience and medical social support level. Medical and nursing personnel should pay attention to its assessment and accurately identify the weak links of family resilience. According to the characteristics of different categories of elderly MHD patients and its influencing factors, multi⁃dimensional nursing intervention strategies can be adopted to promote the improvement of their family resilience.