广西医学

目的探讨超声造影定量参数与卵巢癌患者临床病理参数及病灶血管新生的相关性。方法采用回顾性研究方法，选择105例卵巢癌患者（卵巢癌组）和56例良性卵巢肿瘤患者（对照组）作为研究对象。比较两组患者的超声造影定量参数［始增时间（AT）、达峰时间（TTP）、峰值强度（PI）及增强强度（EI）］。对卵巢癌组进行亚组分析，比较不同亚组内患者超声造影定量参数的差异，并分析卵巢癌组超声造影定量参数与病灶微血管密度（MVD）的相关性。结果卵巢癌组AT、TTP短于对照组，EI、PI高于对照组（P<0.05）。低中度分化、国际妇产科联盟（FIGO）分期Ⅲ期、淋巴结转移及高MVD的卵巢癌患者的AT、TTP 低于高度分化、FIGO分期Ⅰ~Ⅱ期、无淋巴结转移及低MVD的卵巢癌患者，EI、PI高于高度分化、FIGO分期Ⅰ~Ⅱ期、无淋巴结转移及低MVD的卵巢癌患者（P<0.05）。卵巢癌组患者的AT、TTP与MVD呈负相关，EI、PI与MVD呈正相关（P<0.05）。结论卵巢癌患者中，超声造影定量参数AT、TTP缩短，EI、PI增高，且低中度分化、FIGO分期Ⅲ期、有淋巴结转移和高MVD的卵巢癌患者的AT、TTP较短，EI、PI较高。AT、TTP越短，或EI、PI越高的卵巢癌患者，其病灶血管生成活性越强。

Objective To explore the correlation between quantitative parameters of contrast⁃enhanced ultrasound and clinicopathological parameters and lesion neovascularization in patients with ovarian cancer. Methods Employing retrospective study method, 105 patients with ovarian cancer (the ovarian cancer group) and 56 patients with benign ovarian tumors (the control group) were selected as the research subjects. The quantitative parameters of contrast⁃enhanced ultrasound with respect to arrival time (AT), time to peak (TTP), peak intensity (PI), and enhancement intensity (EI) were compared between patients of the two groups. Subgroup analysis was conducted on the ovarian cancer group to compare the differences in quantitative parameters of contrast⁃enhanced ultrasound between patients in various subgroups, and to analyze the correlation between quantitative parameters of contrast⁃enhanced ultrasound and lesion microvascular density (MVD) in the ovarian cancer group. Results The ovarian cancer group exhibited shorter AT and TTP, whereas higher EI and PI as compared with the control group (P<0.05). Ovarian cancer patients with low⁃moderate differentiation, International Federation of Gynecology and Obstetrics (FIGO) in stage Ⅲ, lymphatic metastasis, and high MVD obtained lower AT and TTP, while higher EI and PI as compared with ovarian cancer patients with high differentiation, FIGO in stage Ⅰ-Ⅱ, without lymphatic metastasis, and with low MVD (P<0.05). AT and TTP negatively correlated with MVD, while EI and PI positively correlated with MVD in the ovarian cancer group (P<0.05). Conclusion Among patients with ovarian cancer, quantitative parameters of contrast⁃enhanced ultrasound AT and TTP are shorter, while EI and PI increase. Ovarian cancer patients with low⁃moderate differentiation, FIGO in stage Ⅲ, lymphatic metastasis, and high MVD obtain shorter AT and TTP, and higher EI and PI. The shorter the AT and TTP are, or the higher the EI and PI are, the stronger the lesion neovascularization activity in patients with ovarian cancer is.