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专家账号密码找回目的 探讨HBV基本核心启动子（BCP）A1762、G1764双突变者原发性肝癌（简称肝癌）的发病情况。方法 对广西隆安县1 138名40岁以上HBV BCP A1762、G1764双突变者每半年进行1次肝癌随访，连续随访4年。记录不同年龄组和性别的HBV BCP A1762、G1764双突变者的肝癌发病率，以及随访人群的体检情况。结果 共随访4 378.47人年，肝癌发病率1 027.76/10万人年，男性肝癌发病率高于女性（P<0.05），肝癌发病率与年龄无相关趋势（P>0.05）。彩超异常率为50.04%，主要表现为肝实质回声增粗（49.46%）和脂肪肝（23.52%）。甲胎蛋白阳性率为3.08%。体检参与率为48.32%，有791名至少参加过1次体检，其中8次体检者占比最高（26.30%），1次体检者占比最低（5.44%）。结论 HBV BCP A1762、G1764双突变者肝癌发生率较高，且男性发生率高于女性，应加强高危人群肝癌早筛工作，提高肝癌早诊早治效率。
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论著·调查与研究
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更新时间：2025-11-05
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HBV基本核心启动子Ａ1762、G1764双突变者原发性肝癌筛查与随访研究
Screening and follow⁃up studies of primary liver cancer in individuals with HBV basal core promoter A1762 and G1764 amphimutation
广西医学 页码：1469-1473
作者机构：胡莉萍，硕士，主管医师，研究方向为病毒性肝炎防治。
基金信息：国家自然科学基金（81860595，81703283）；广西高校中青年教师科研基础能力提升项目（2024KY1238）
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- 英文简介
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Objective To explore the morbidity of primary liver cancer (hereinafter referred to as liver cancer) in individuals with HBV basal core promoter (BCP) A1762 and G1764 amphimutation. Methods Follow⁃up of liver cancer was performed once every 6 months on 1138 HBV BCP A1762 and G1764 amphimutation individuals aged >40 years in Long’an County, Guangxi Zhuang Autonomous Region, for a continuous 4⁃year follow⁃up. The incidence rate of liver cancer in individuals with HBV BCP A1762 and G1764 amphimutation in various age groups and genders was recorded, and the check⁃up status was also recorded in follow⁃up populations. Results A total of 4378.49 person⁃years were followed up. The incidence rate of liver cancer was 1027.76/100 000 person⁃years, with higher incidence rate in males than females (P<0.05). There was no correlation trend between the incidence rate of liver cancer and age (P>0.05). The abnormal rate of color Doppler ultrasound was 50.04%, mainly manifested as coarse liver parenchymal echoes (49.46%) and fatty liver (23.52%). The positive rate of alpha fetoprotein was 3.08%. The check⁃up participation rate was 48.32%, with 791 individuals having participated in at least one check⁃up. Among them, those who had undergone eight times of check⁃up accounted for the highest proportion (26.30%), while those who had only participated once made up the lowest proportion (5.44%). Conclusion The incidence rate of liver cancer in individuals with HBV BCP A1762 and G1764 amphimutation is relatively high, and the incidence rate is higher in males than in females. Early screening work for liver cancer among high⁃risk populations should be strengthened, and the efficiency of early diagnosis and treatment of liver cancer should be improved.
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