Extracorporeal membrane oxygenation (ECMO), as an important life support technique, plays a critical role in the treatment of critically ill patients. However, the complexity of ECMO system poses a challenge on patients' pharmacotherapy. This paper summarizes how ECMO influences the pharmacokinetic properties of different categories of drugs through drug adsorption, volume of distribution, and clearance rate. Simultaneously, this paper also discusses the differences in effects of ECMO treatment on drug pharmacokinetics between different patient groups such as adults and children, as well as the effects of ECMO combined with renal replacement therapy on drug pharmacokinetics. In addition, this paper analyzes the limitations of existing research and look forward to the future research directions, aiming at providing references for medical and nursing personnel who are engaged in ECMO technique, and optimizing individualized management of ECMO patients' drug therapy.

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