ute coronary syndrome (ACS) after percutaneous coronary intervention (PCI). Methods A total of 162 ACS patients were selected as the research subjects, and they were divided into infection group (n=14) or non⁃infection group (n=148) according to the presence of hospital⁃acquired infection occurred after PCI. Sites, pathogens, and influencing factors for hospital⁃acquired infection in ACS patients after PCI were analyzed. The predictive model based on the influencing factors was established to evaluate the predictive value on hospital⁃acquired infection in ACS patients after PCI. Results Respiratory system (64.29%) was the main hospital⁃acquired infection site in ACS patients after PCI. A total of 19 bacterial strains were detected, including 12 Gram⁃negative bacteria, 6 Gram⁃positive bacteria, and 1 fungus. The blood creatinine level of the infection group was higher than that of the non⁃infection group, while hemoglobin and albumin levels were lower in the infection group than in the non⁃infection group (P<0.05). Blood creatinine level elevation was identified as a risk factor for hospital⁃acquired infection in ACS patients after PCI, whereas the elevations of hemoglobin and albumin levels were the protective factors for hospital⁃acquired infection in ACS patients after PCI (P<0.05). The sensitivity, specificity, and area under the curve of the predictive model for predicting hospital⁃acquired infection in ACS patients after PCI were 0.820, 0.740, and 0.843, respectively. Conclusion The main site of hospital⁃acquired infection in ACS patients after PCI is the respiratory system, and Gram⁃negative bacteria are the main infectious bacteria. Hospital⁃acquired infection in ACS patients after PCI is related to the abnormal levels of blood creatinine, hemoglobin and albumin. The predictive model established based on the above factors can be used as a clinical tool for early identification of high⁃risk patients.

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