As one of the major health hazards and causes of death in the world, occupational diseases bring heavy economic and social burden to various countries in the world. At present, Guangxi Zhuang Autonomous Region is undergoing the rapid development of industrialization and urbanization. Occupational health problems brought by extensive development over the years have gradually appeared, the occupational health demands of workers are increasing, and occupational health work needs to be strengthened. Occupational disease diagnosis is one of the core contents of occupational health work. The Market Supervision and Administration of Guangxi Zhuang Autonomous Region issued the Standard for Diagnosis of Occupational Diseases (DB45/T 2771-2023) on 12th December, 2023, which clarified the scope of application of the standard. It specifies relevant terms and definitions, principles of occupational disease diagnosis, requirements for occupational disease diagnosis institutions, procedures for occupational disease diagnosis, management of occupational disease diagnosis files, and occupational disease case reports, etc., with 8 informative appendices. The promulgation and implementation of the standard provide technical standards for various occupational disease diagnosis institutions in the whole region. This paper interprets the main contents of the standard, aiming at promoting the publicity and implementation of the standard.