Objective To analyze the characteristics of new⁃onset cases of occupational diseases in Liuzhou from 2006 to 2023, so as to provide a scientific basis for the prevention, control, and management of occupational diseases. Methods Data of new⁃reported cases with occupational diseases in Liuzhou from 2006 to 2023 were collected through the Occupational Disease and Health Hazard Monitoring Information System. Descriptive statistical analysis was performed on demographic characteristics, distribution of disease categories, time distribution, regional distribution, and industry classification of cases, etc. Results (1) A total of 262 new⁃onset cases of occupational diseases were reported in Liuzhou from 2006 to 2023, which were male⁃dominated (accounting for 90.46%), with the average onset age of 50.44 years old, and the median working age of injury was 20.5 years. (2) The top three categories were occupational pneumoconiosis and other respiratory diseases (65.27%), occupational chemical poisoning (21.37%), and occupational otorhinolaryngological and oral diseases (11.83%), mainly pneumoconiosis, acute hydrogen sulfide poisoning, and occupational noise⁃induced deafness, respectively. (3) From 2006 to 2014, pneumoconiosis was the primary new⁃onset occupational disease, while from 2015 to 2023, occupational noise⁃induced deafness became predominant in Liuzhou. (4) Pneumoconiosis cases were mainly distributed in Liubei District (81.65%), occupational chemical poisoning was most prevalent in Chengzhong District (37.50%), and occupational noise⁃induced deafness was primarily reported in Liunan District and Luzhai County (70.00%). (5) Cases of pneumoconiosis were mainly concentrated in ferrous/non⁃ferrous metal smelting and calendering industry (80.38%), of occupational chemical poisoning in paper and paper products industry (39.29%), and of occupational noise⁃induced deafness in chemical raw materials and chemical products manufacturing industries as well as other machinery manufacturing industries (63.33%). (6) New⁃onset cases of occupational diseases in Liuzhou were mainly concentrated in state⁃owned enterprises (70.23%) or large and medium⁃sized enterprises (81.68%). Conclusion From 2006 to 2023, the number of new⁃onset cases with occupational diseases in Liuzhou reveals an overall downward trend, and the distribution of regions, industries and enterprises in cases has an obvious concentration trend. With the changes in the morbidity trend and disease spectrum of occupational diseases, the focus of occupational disease prevention and control works should be adjusted accordingly. It is suggested to further improve the level of occupational disease prevention and control in key areas, key industries and enterprises with serious hazards, and effectively protect the occupational health rights of workers relying on the special control of occupational disease hazards in Guangxi.