Anemia is a common complication of chronic kidney disease (CKD) in children. It often occurs in stage 3 of CKD and is often manifested as fatigue and discomfort, loss of appetite, and poor exercise tolerance, etc. In severe cases, there will be dizziness, dyspnea, and cardiovascular related manifestations, which seriously affect the growth and development of children and the quality of their life. Anemia is not only a clinical manifestation of CKD, but also an important marker of disease progression, which needs to be paid enough attention. Current studies have reveled that the etiology of anemia in children with CKD is complex, involving a variety of factors such as erythropoietin (EPO) resistance or relative insufficient production, insufficient raw materials for erythropoiesis, and effects of cytokines inhibition. This paper reviews the pathogenesis and treatment progress of anemia in children with CKD, especially the supplement of iron deficiency, the application of EPO, and the use of novel therapeutic drugs, aiming at better addressing the challenges posed by anemia in children with CKD.

无