广西医学

目的探讨颊针疗法联合口服正清风痛宁缓释片治疗带状疱疹后神经痛（PHN）的临床效果。方法将150例PHN患者随机分为对照组和观察组，各75例。对照组采取常规治疗，观察组在对照组的基础上加用颊针疗法联合口服正清风痛宁缓释片治疗，两组均治疗2周。比较两组患者治疗前、治疗2周后的疼痛视觉模拟量表（VAS）评分、匹兹堡睡眠质量指数（PSQI）评分、炎症指标［白细胞介素（IL）⁃6、IL⁃1β、肿瘤坏死因子α（TNF⁃α）］、血液流变学指标［全血黏度低切、全血黏度高切］及36项健康状况调查简表（SF⁃36）评分，以及普瑞巴林用量、不良反应发生情况。结果治疗2周后，两组患者的疼痛VAS评分、PSQI评分，血清IL⁃6、IL⁃1β、TNF⁃α水平，全血黏度低切、全血黏度高切低于治疗前，且观察组的上述指标低于对照组（P<0.05）。治疗2周后，两组患者的SF⁃36各维度得分及总分高于治疗前，且观察组的SF⁃36各维度得分及总分高于对照组（P<0.05）。观察组的普瑞巴林用量少于对照组（P<0.05）。两组患者的不良反应总发生率比较，差异无统计学意义（P>0.05）。结论采取颊针疗法联合口服正清风痛宁缓释片治疗PHN，可减轻患者的疼痛程度及炎症反应，改善睡眠质量及血液流变学指标，提高生活质量，且安全性较高。

Objective To investigate the clinical effect of cheek acupuncture therapy combined with oral administration of Zhengqing Fengtongning Sustained⁃Release Tablets for the treatment of postherpetic neuralgia (PHN). Methods A total of 150 patients with PHN were randomly divided into control group or observation group, with 75 cases in each group. The control group received conventional treatment, based on which the observation group additionally received cheek acupuncture therapy combined with oral administration of Zhengqing Fengtongning Sustained⁃Release Tablets for treatment. Both groups received a 2⁃week treatment. Pre⁃treatment and two⁃week post⁃treatment Visual Analogue Scale (VAS) score for pain, Pittsburgh sleep quality index (PSQI) score, inflammatory indicators including interleukin (IL)⁃6, IL⁃1β, tumor necrosis factor alpha (TNF⁃α), hemorheological indicators (low viscosity of whole blood, high viscosity of whole blood), and 36⁃Item Short⁃Form Healthy Survey (SF⁃36) score, pregabalin dosage, and incidence rate of adverse reactions were compared between the two groups. Results After two weeks of treatment, both groups exhibited decreased scores of VAS for pain and PSQI, and decreased serum levels of IL⁃6, IL⁃1β, and TNF⁃α, as well as decreased low viscosity and high viscosity of whole blood as compared with before treatment; moreover, the observation group yielded lower indices as above as compared with the control group (P<0.05). After two weeks of treatment, both groups interpreted elevated scores in various dimensions of SF⁃36 and total score of SF⁃36 as compared with before treatment, and the observation group expressed higher scores in various dimensions of SF⁃36 and total score of SF⁃36 as compared with the control group (P<0.05). Pregabalin dosage of the observation group was less than that of the control group (P<0.05). There was no statistically significant difference in the total incidence rate of adverse reactions between the two groups (P>0.05). Conclusion Cheek acupuncture therapy combined with oral administration of Zhengqing Fengtongning Sustained⁃Release Tablets for the treatment of PHN can reduce the pain degree and inflammatory response of patients, improve sleep quality, regulate hemorheological indicators, and improve the quality of life of patients, exerting safety to a certain extent.

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