A major infectious disease epidemic refers to a certain infectious disease that spreads rapidly within a relatively short period, has a wide impact, and cause a large number of infections or deaths. Its typical feature is that the morbidity or fatality rate is significantly higher than the annual average level of the disease. Major infectious diseases not only endanger human health, but also seriously affect global economic development, social stability and national security. This paper mainly explores the epidemic situation of major infectious diseases and the main challenges in the field of infectious disease prevention and control in Guangxi Zhuang Autonomous Region, and puts forward relevant development strategies, aiming at providing references for policy makers, public health experts and researchers, and jointly promoting the high⁃quality development of infectious disease prevention and control in Guangxi Zhuang Autonomous Region.

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