Objective To analyze the epidemiological and clinical characteristics of patients with chikungunya fever. Methods The epidemiological history and clinical data of 50 patients with chikungunya fever were retrospectively analyzed, and their epidemiological characteristics, clinical manifestations, laboratory indicators, and clinical outcome were analyzed. Results (1) All 50 chikungunya fever cases were mild, comprising 25 males and 25 females, aged 6-89 (44.3±2.6) years. Among them, 17 patients had underlying diseases, 3 had a clear history of exposure in epidemic areas (Lecong Town, Foshan), and 4 lived in residences with confirmed chikungunya fever cases, while 43 had no history of exposure to epidemic areas. There were two family clusters involving 5 patients. The time from symptom onset to medical consultation ranged from 2 to 168 hours, with a median time of 52 hours. (2) The clinical manifestations were primarily fever, arthralgia, and rash. Among them, 25 patients presented with the classic triad of fever, arthralgia, and rash, whereas 16 patients exhibited any two of these aforementioned symptoms. Fever occurred in 44 patients, mainly low to moderate grade. Arthralgia was reported in 39 patients, with 33 cases presenting as bilateral symmetric joint pain, most commonly involving the wrists. A rash was observed in 35 patients, mostly characterized as disseminated erythematous maculopapular rash throughout the body. (3) Eight patients presented with leukopenia, 15 exhibited elevated C⁃reactive protein level, 8 had abnormal liver function, 4 indicated elevated serum creatinine level, 4 had increased myocardial enzymes level, and 9 demonstrated elevated uric acid level. Abnormal electrocardiogram findings were observed in 37 patients, predominantly showing ST⁃segment changes. (4) The length of hospital stay ranged from 2 to 8 days, with a mean of 5.2 days. Forty⁃five patients were discharged after being cured or improved and meeting the deisolation criteria. At discharge, 11 patients retained minor residual old rashes, and 7 still experienced mild arthralgia. Conclusion Chikungunya virus is transmitted through mosquito⁃borne bites, mainly manifested by fever, arthralgia and rash. The clinical symptoms of most cases are typical, with a short course of disease, mild condition, few complications and mild severity, and a good prognosis.

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