Objective To analyze the fear of progression (FoP) level and its influencing factors for middle⁃aged and elderly patients with primary glaucoma. Methods A total of 153 middle⁃aged and elderly patients with primary glaucoma were selected as the research subjects. Questionnaire investigations were conducted by using the general information questionnaire, Fear of Progression Questionnaire⁃Short Form (FoP⁃Q⁃SF), Glaucoma Medication Self⁃Efficacy Scale (GMSES), Perceived Social Support Scale (PSSS), and Hospital Anxiety and Depression Scale (HADS). Results The total score of FoP⁃Q⁃SF in middle⁃aged and elderly patients with primary glaucoma was 34.42±2.49. There were statistically significant differences in the total score of FoP⁃Q⁃SF between middle⁃aged and elderly primary glaucoma patients with different age, per capita monthly income, living status, disease course, and number of concomitant chronic diseases (P<0.05), among them, middle⁃aged and elderly patients with primary glaucoma aged 45-59, with a per capita monthly income of less than 3000 yuan, living alone, having a disease course of less than 2 years, and having ≥2 concomitant chronic diseases had a higher total score of FOP⁃Q⁃SF (P<0.05). The total FoP⁃Q⁃SF score negatively correlated with the total scores of GMSES and PSSS, and positively correlated with the total scores of anxiety subscale and depression subscale of HADS (P<0.05). Per capita monthly income, living status, disease course, number of concomitant chronic diseases, GMSES total score, PSSS total score, total scores of anxiety and depression subscales of HADS were the influencing factors for FoP level in middle⁃aged and elderly patients with primary glaucoma (P<0.05). Conclusion FoP in middle⁃aged and elderly patients with primary glaucoma is at a medium to high level, and it is affected by factors such as per capita monthly income, living status, disease course, number of concomitant chronic diseases, glaucoma medication self⁃efficacy, perceived social support level, anxiety, and depression.