Traditional Chinese Medicine primarily relies on “disease⁃pattern combination” and “static pattern differentiation”. However, when confronting severe diseases characterized by insidious onset and rapid progression, it often struggles to achieve early intervention aligned with the principle of “preventive treatment” due to “delayed manifestation of patterns” and the “absence of discernible patterns”. This study employs a research methodology integrating theoretical construction and case validation to systematically elaborate on the theoretical core of the “Five⁃Element Ten⁃State Constitution” as an “internal spatiotemporal” coordinate. It constructs a spatiotemporal pathogenesis deduction model encompassing five temporal nodes as follows: onset, manifestation, transmission, resolution tendency, and consultation, and it constructs the three⁃dimensional model of “qi movement⁃constitution⁃disease pattern”, which is applied to deduce, and retrospectively analyze typical severe and complex cases, with comparisons made to traditional pattern differentiation methods. This model embodies the core principle of the unity of heaven and humanity, represents a shift in clinical thinking from “static pattern differentiation” to “dynamic deduction”, and enable earlier prediction of disease progression trends and more precise identification of key pathological junctures. It provides a foundation for personalized treatment strategies targeting “co⁃existing patterns”, thereby significantly optimizing the decision⁃making process for severe and complex diseases and enhancing the foresight and precision of interventions.

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