Zuojin Pills, recorded in Danxi Xinfa (a classic of Traditional Chinese Medicine from Yuan dynasty), is composed of Coptis chinensis and Evodia rutaecarpa. It possesses pharmacological effects such as antibacterial and anti⁃inflammatory actions, repair of gastric mucosal damage, antitumor activity, regulation of immune function, and modulation of gastrointestinal function. Clinically, it is commonly used to treat digestive system diseases including gastroesophageal reflux disease, functional dyspepsia, chronic gastritis, ulcerative colitis, and irritable bowel syndrome. By reviewing recent research findings on Zuojin Pills, this paper systematically elaborates on the active components, pharmacological effects of both the individual herbs and the formula, as well as the research progress on its treatment for digestive system diseases, aiming to provide references for further in⁃depth study of the Zuojin Pills compound and its expanded clinical application in digestive system diseases.

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