There is a significant regional difference in the disease burden of upper gastrointestinal cancer in Guangxi Zhuang Autonomous Region (hereinafter referred to as Guangxi). The morbidity and mortality of upper gastrointestinal cancer in Western Guangxi and other areas are higher than the national average level, and the risk of disease in rural areas and male population is particularly prominent. In recent years, through the construction of a provincial⁃city⁃county three⁃level screening network, and the promotion of opportunistic screening mode and technological innovation (magnifying chromoendoscopy combined with liquid biopsy, molecular marker detection technology, etc.), the early diagnosis rate of upper gastrointestinal cancer and the 5⁃year survival rate after endoscopic submucosal dissection in Guangxi have been significantly improved. However, the performance of prevention and control of upper gastrointestinal cancer in Guangxi is still restricted by the uneven coverage of screening, weak diagnostic capacity at primary level, contradictory allocation of treatment resources, and lagging technology transformation and data integration. This paper systematically reviews the current status and challenges of the screening, early diagnosis and early treatment of upper gastrointestinal cancer in Guangxi, and puts forward targeted optimization strategies, aiming to provide a scientific basis and practice guidance for improving control and prevention levels of upper gastrointestinal cancer in Guangxi.

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