Post⁃stroke depression (PSD) is a common emotional disorder complication after cerebral stroke, seriously affecting neurological functional recovery and quality of life in patients. Influenced by the hot and humid climate of Guangxi Zhuang Autonomous Region (hereinafter referred to as Guangxi), residents have a dampness⁃turbidity constitution, and the clinical manifestation, diagnosis and treatment of PSD possess regional characteristics. Integrated Traditional Chinese and Western Medicine therapy has demonstrated unique advantages in alleviating PSD core symptoms, promoting functional recovery, and reducing the side effects of Western Medicines. To standardize diagnostic and therapeutic practice, the Neurology Branch of Guangxi Society of Integrated Traditional Chinese and Western Medicine organized experts of related disciplines to formulate the Expert Consensus on Integrated Traditional Chinese and Western Medicine Diagnosis and Treatment of Post⁃Stroke Depression in Guangxi. It systematically integrates international and domestic evidence⁃based medical findings, clinical practical experience, and the distinctive features of the Guangxi region. The consensus clarifies the Western medical diagnostic criteria, assessment tools, differentiated diagnosis, and pharmacological treatment regimens for PSD. Concurrently, it elaborates on the etiology and pathogenesis according to Traditional Chinese Medicine, syndrome differentiation patterns (with particular emphasis on Lingnan⁃specific patterns such as phlegm⁃heat harassing the spirit), and corresponding herbal prescriptions; furthermore, acupuncture⁃moxibustion therapy, Tuina therapy and the characteristic therapies of Zhuang Medicine are mainly recommended. This consensus aims to provide clinicians with a practical reference for PSD diagnosis and treatment that combines the strengths of Traditional Chinese and Western Medicine, embodies both standardization and regional characteristics, and ultimately seeks to improve the early detection rate and clinical efficacy of PSD in Guangxi region, fostering the inheritance and development of ethnic medicine and the comprehensive rehabilitation of stroke patients.