Colorectal cancer (CRC) is a high‑incidence malignancy in China, and reducing its disease burden remains a core public‑health challenge. The epidemiological profile in Guangxi Zhuang Autonomous Region (hereinafter referred to as Guangxi) CRC presents as “male predominance, pronounced urban⁃rural disparities, and an emerging early‑onset trend”. Under the government leadership and with coordinated support from the health and wellness⁃medical insurance⁃finance, Guangxi has established a life‑course integrated comprehensive prevention and control network for CRC, namely, primary prevention emphasizes locally adapted health interventions and the translation of gut microbiome research into practice. Secondary prevention has developed a precision screening system that integrates host genes with intestinal flora characteristics, which is significantly improved for early⁃diagnosis rate by the population⁃level validation. Tertiary prevention is based on the framework of “provincial multidisciplinary team (MDT) diagnosis centers+municipal sub⁃centers+grassroots rehabilitation points”, promoting individualized diagnosis and treatment as well as full⁃process rehabilitation management, and improving survival and the quality of life of patients. Taking Guangxi as an example, this paper systematically reviews and assesses the innovative strategies and practical achievements of its comprehensive CRC prevention and control mode. In light of the requirements set out in the “15th Five⁃Year Plan”, it also proposes countermeasures to address the current challenges faced in prevention and control, such as insufficient resource balance and the need to improve the efficiency of technology transfer.

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