Objective To investigate the safety, effectiveness, and health economic value of uni⁃portal non⁃coaxial spinal endoscopic surgery (UNSES) in the day surgery mode for the treatment of lumbar spinal stenosis (LSS). Methods A retrospective analysis was conducted on the clinical data of 44 LSS patients. Patients were divided into day surgery group (24 cases) or conventional hospitalization group (20 cases) according to surgical modes. Both groups underwent UNSES for treatment. Safety indices, effectiveness indices, and health economic indices were compared between patients of the two groups. Results (1) Safety indices: there was no statistically significant difference in operation duration, anesthesia duration, intraoperative bleeding volume, postoperative drainage catheter indwelling time and total drainage volume, the incidence rates of operation⁃ and anesthesia⁃related complications, and the reoperation rate between the patients of the two groups (P>0.05). (2) Effectiveness indices: 3 months after surgery, patients of both groups obtained ameliorated Visual Analogue Scale score for waist and legs pain, Japanese Orthopaedic Association score, and Oswestry disability index score compared with before surgery (P<0.05), but there was no statistically significant difference in aforementioned scores and satisfaction between patients of the two groups (P>0.05). (3) Health economic indices: the day surgery group exhibited shorter preoperative waiting time, shorter length of hospital stays, and a lower total hospitalization expense compared with the conventional hospitalization group (P<0.05). Conclusion UNSES in the day surgery mode is safe and effective for treating LSS, achieving comparable efficacy to conventional hospitalization. However, it shortens preoperative waiting times and length of hospital stays, and reduces medical expense.

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