As a cell⁃free therapeutic medium, adipose⁃derived stem cell derived exosomes (ADSC⁃Exos) are involved in the regulation of key biological processes such as angiogenesis, inflammatory response, autophagy, cell apoptosis and differentiation by delivering functional molecules such as miRNA and circular RNA. ADSC⁃Exos play a therapeutic role in many disease fields such as skin injury, pulmonary injury, liver ischemia⁃reperfusion injury, and female reproductive system diseases by promoting the repair of tissue structure and function. However, ADSC⁃Exos interpret bidirectional effects of engineered tumor suppression and natural tumor promotion in tumor intervention. This paper systematically reviews the mechanism and application prospect of ADSC⁃Exos in tissue repair and disease treatment.

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