Adipose⁃derived stem cells (ADSCs) have become a research hotspot in the field of musculoskeletal system regenerative medicine due to their abundant sources, multi⁃directional differentiation potential and strong paracrine function. ADSCs and their derivatives provide diverse and promising strategies for the treatment of musculoskeletal system diseases through a variety of ways, such as direct effects of stem cells, paracrine effects, and combined biomaterials, other biological agents or therapeutic strategies. This paper systematically reviews the application and research progress on ADSCs and their derivatives in the fields of osteoarthritis, chondrogenic differentiation and cartilage repair, systemic bone loss, bone defect repair and spinal fusion, tendon⁃ligament repair/reconstruction, aiming to provide a theoretical basis for subsequent clinical application and product development.

无