Immunosuppressive therapy is the core link of management after organ transplantation, but how to prevent and treat immune rejection is still a major problem for clinicians. Bone marrow mesenchymal stem cells (BMMSCs) have multi⁃directional differentiation potential and can differentiate into a variety of cell types, creating the possibility for tissue repair and regeneration. At the same time, they have immunomodulatory ability, so they have become a research hotspot in the field of immune tolerance after organ transplantation. This review focuses on the induction effects of immune tolerance by BMMSCs after organ transplantation, the possible mechanism and the latest progress on clinical frontier application, aiming to provide new ideas for the prevention and treatment of immune rejection after organ transplantation.

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