经导管动脉栓塞术是微创介入医学的核心技术,栓塞材料的结构与性能直接决定栓塞治疗的疗效。本文综述固体、液体、液-固相转化型及多功能栓塞材料的研究进展。各类栓塞材料经过改良均实现性能提升,液-固相转化型可精准载药,多功能栓塞材料推动栓塞治疗的模式升级。目前栓塞材料已实现从单纯、单一级别的血管阻塞到多平面栓塞、释放多种药物精准治疗的多功能跨越,但仍面临生物相容性、响应精度、操作可控性与临床转化等挑战。多学科交叉融合是新型栓塞材料研发的重要方向,为介入栓塞治疗的技术革新和疗效提高提供参考。
广西医学 页码:1266-1274
作者机构:赵亚楠,理学博士,助理研究员、硕士研究生导师,研究方向为天然高分子基栓塞材料和多功能气道支架的研发与临床转化。
基金信息:河南省中青年卫生健康科技创新优青人才项目(YQRC2024014);“科创中原”行动项目(2025HYTP094);河南省自然科学基金青年项目(252300421764);河南省高等学校重点科研项目计划(25A320034)
经导管动脉栓塞术是微创介入医学的核心技术,栓塞材料的结构与性能直接决定栓塞治疗的疗效。本文综述固体、液体、液-固相转化型及多功能栓塞材料的研究进展。各类栓塞材料经过改良均实现性能提升,液-固相转化型可精准载药,多功能栓塞材料推动栓塞治疗的模式升级。目前栓塞材料已实现从单纯、单一级别的血管阻塞到多平面栓塞、释放多种药物精准治疗的多功能跨越,但仍面临生物相容性、响应精度、操作可控性与临床转化等挑战。多学科交叉融合是新型栓塞材料研发的重要方向,为介入栓塞治疗的技术革新和疗效提高提供参考。
Transcatheter arterial embolization serves as a core technique for minimally invasive interventional medicine. The structure and properties of embolization materials directly determine the efficacy of embolization. This paper reviews the research progress on solid, liquid, liquid⁃to⁃solid phase transition, and multifunctional embolization materials. The performance of various embolization materials has been improved via modification. Liquid⁃to⁃solid phase transition materials enable precise drug loading, and multifunctional embolization materials drive the upgrading of embolization⁃therapy modalities. At present, embolization materials have achieved a multifunctional leap from simple, single⁃level vascular occlusion to multi⁃plane embolization and multi⁃drug release for precise treatment. However, there are still challenges such as biocompatibility, response accuracy, operational controllability, and clinical transformation. Multidisciplinary integration is an important direction for the research and development of new embolization materials, which provides a reference for the technical innovation and efficacy improvement of interventional embolization.