Malignant obstructive jaundice (MOJ) is a group of disorders caused by direct invasion or compression of the biliary system by malignant tumors, leading to impaired bile excretion. The disease has an insidious onset and lacks specific clinical symptoms in its early stages. Most patients are already ineligible for radical surgical resection by the time of diagnosis. Although biliary stent implantation can promptly relieve biliary obstruction and restore drainage function, the stent itself does not possess anti⁃tumor effects. Due to factors such as tumor progression or intimal hyperplasia, stent is prone to occlusion, resulting in recurrent biliary obstruction. In recent years, 125I seed combined with biliary stent implantation has become a commonly used palliative treatment regimen for MOJ. Without increasing the risk of postoperative complications, this approach can prolong stent patency and overall patient survival; furthermore, the combination with hepatic arterial infusion chemotherapy can enhance the anti⁃tumor efficacy. This paper provides a systematic review of the application of 125I seed combined with biliary stent implantation for the treatment of MOJ, aiming to provide theoretical basis and reference for clinical practice.

无