Perineural invasion (PNI) has emerged as a critical route of tumor metastasis and thus garnered growing attention. Accumulating evidence indicates that PNI in pulmonary carcinoma correlates with tumor progression, elevated risk of local recurrence, and declined overall survival rate in patients. At present, the occurrence mechanism of PNI in pulmonary carcinoma is still limited. This paper reviews the research on PNI in recent years, with a focus on analyzing the potential mechanism underlying PNI formation in pulmonary carcinoma and the relation between PNI and the prognosis of patients with pulmonary carcinoma, aiming to provide a new theoretical reference for the clinical treatment of pulmonary carcinoma.

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